Hiroyuki Shibata Selected Research

1,5- bis(3,5- bis(methoxymethoxy)phenyl)penta- 1,4- dien- 3- one

12/2021	Curcumin analog GO-Y030 boosts the efficacy of anti-PD-1 cancer immunotherapy.
1/2020	The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice.
12/2017	Curcumin Analogue GO-Y030 Significantly Improves Pressure Overload-induced Heart Failure in Vivo.
10/2015	Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.
1/2015	Targeting the NF-κB Pathway as a Combination Therapy for Advanced Thyroid Cancer.
11/2011	Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents with enhanced abilities for multiple myeloma.
5/2011	Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo.
5/2011	Curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis.
10/2009	Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.
5/2009	Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo.

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Hiroyuki Shibata Research Topics

Disease

42	Neoplasms (Cancer) 01/2022 - 02/2003
7	Colorectal Neoplasms (Colorectal Cancer) 04/2021 - 07/2005
6	Stomach Neoplasms (Stomach Cancer) 01/2022 - 12/2004
6	Neoplasm Metastasis (Metastasis) 04/2017 - 07/2005
6	Carcinogenesis 10/2015 - 12/2004
3	Melanoma (Melanoma, Malignant) 12/2021 - 07/2006
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2020 - 07/2017
3	Pancreatic Neoplasms (Pancreatic Cancer) 03/2020 - 10/2009
3	Breast Neoplasms (Breast Cancer) 11/2017 - 02/2008
3	Esophageal Neoplasms (Esophageal Cancer) 01/2016 - 12/2006
3	Carcinoma (Carcinomatosis) 08/2007 - 12/2004
2	Atrial Fibrillation 01/2022 - 01/2017
2	Neutropenia 01/2021 - 12/2006
2	Heart Failure 01/2020 - 12/2017
2	Hypophosphatemia 04/2017 - 06/2010
2	Thyroid Neoplasms (Thyroid Cancer) 01/2015 - 05/2011
2	Hypercalcemia (Milk Alkali Syndrome) 06/2010 - 12/2008
2	Hyponatremia 06/2010 - 12/2008
2	Adenoma (Adenomas) 05/2009 - 11/2007
2	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 11/2007 - 01/2002
1	Neuroendocrine Carcinoma 01/2022
1	Tachycardia (Tachyarrhythmias) 01/2022
1	Autoimmune Diseases (Autoimmune Disease) 01/2022
1	Cardiotoxicity 01/2022
1	Disease Progression 01/2022
1	Diamond-Blackfan Anemia (Anemia, Diamond Blackfan) 12/2020
1	Anemia 12/2020
1	Adenocarcinoma of Lung 09/2020
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 04/2020
1	Hepatocellular Carcinoma (Hepatoma) 04/2020
1	Hypertrophy 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Cardiomegaly (Heart Hypertrophy) 01/2020
1	Air Embolism (Gas Embolism) 01/2019
1	Flushing 01/2019
1	Acute Coronary Syndrome 11/2018
1	Atherosclerotic Plaque (Atheroma) 11/2018
1	Thrombosis (Thrombus) 11/2018

Drug/Important Bio-Agent (IBA)

14	CurcuminIBA 12/2021 - 10/2006
10	1,5- bis(3,5- bis(methoxymethoxy)phenyl)penta- 1,4- dien- 3- oneIBA 12/2021 - 05/2009
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2002
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 03/2012
4	Fluorouracil (Carac)FDA LinkGeneric 12/2020 - 07/2005
4	Paclitaxel (Taxol)FDA LinkGeneric 08/2019 - 07/2005
4	beta CateninIBA 05/2009 - 01/2002
3	Immune Checkpoint InhibitorsIBA 01/2022 - 12/2021
3	Pharmaceutical PreparationsIBA 01/2021 - 01/2015
3	GO-Y078IBA 10/2018 - 11/2011
3	Biological ProductsIBA 07/2016 - 10/2006
3	Cisplatin (Platino)FDA LinkGeneric 01/2016 - 12/2006
3	DNA (Deoxyribonucleic Acid)IBA 03/2012 - 02/2003
2	LigandsIBA 01/2022 - 07/2017
2	Programmed Cell Death 1 ReceptorIBA 12/2021 - 07/2017
2	Angiogenesis InhibitorsIBA 04/2021 - 10/2018
2	Carboplatin (JM8)FDA LinkGeneric 10/2020 - 08/2019
2	Gemcitabine FDA Link 10/2020 - 06/2013
2	Therapeutic UsesIBA 09/2020 - 07/2017
2	Bevacizumab (Avastin)FDA Link 08/2019 - 07/2018
2	Adenosine Triphosphate (ATP)IBA 11/2017 - 07/2009
2	Cytotoxins (Cytolysins)IBA 04/2017 - 07/2009
2	Docetaxel (Taxotere)FDA Link 01/2015 - 12/2006
2	Codon (Codons)IBA 03/2012 - 11/2007
2	AcetoneIBA 09/2010 - 02/2010
2	Vasopressins (Vasopressin)IBA 06/2010 - 12/2008
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022
1	Chimeric Antigen ReceptorsIBA 01/2022
1	Aligeron (AS 2)IBA 01/2022
1	Polysaccharides (Glycans)IBA 01/2022
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022
1	pembrolizumabIBA 01/2022
1	IodineIBA 01/2022
1	Contrast MediaIBA 01/2022
1	alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferaseIBA 01/2022
1	IceIBA 01/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 12/2021
1	afliberceptIBA 04/2021
1	Trifluridine (Viroptic)FDA LinkGeneric 01/2021
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2021
1	trifluridine tipiracil drug combinationIBA 01/2021
1	ribosomal protein S19IBA 12/2020
1	Cetuximab (Erbitux)FDA Link 12/2020
1	Ribosomal Proteins (Ribosomal Protein)IBA 12/2020
1	DiamondIBA 12/2020
1	osimertinibIBA 09/2020
1	Tyrosine Kinase InhibitorsIBA 04/2020
1	regorafenibIBA 04/2020
1	Histones (Histone)IBA 01/2020
1	AcetyltransferasesIBA 01/2020
1	Prasugrel Hydrochloride FDA Link 11/2018

Therapy/Procedure

21	Drug Therapy (Chemotherapy) 04/2021 - 07/2005
6	Therapeutics 01/2021 - 07/2006
2	Immunotherapy 01/2022 - 12/2021
2	Catheter Ablation 01/2019 - 01/2017
2	Stents 11/2018 - 05/2016
2	Esophagectomy 01/2016 - 07/2005
2	Chemoradiotherapy 04/2013 - 07/2006
1	Intra-Aortic Balloon Pumping 01/2022
1	Adjuvant Chemotherapy 10/2020
1	Induction Chemotherapy 08/2019
1	Catheters 01/2019